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1,2-dioleoyl-3-dimethylammonium propane, DODAP

1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

1,2-dioleoyl-3-dimethylammonium propane, DODAP

DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid  (pKa = 5.59 in a TNS binding assay) with lower cytotoxicity and high transfection efficiency. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a disease treatment.

Contact us at contact@pbiolabs.com to learn more about our clinical-grade and research-grade DODAP manufacturing.

No Returns or refunds on the custom orders.

SKU: DODAP-CR - XXG Categories: , Tags: , , , , , ,

Description

Synonyms:

  • DODAP
  • 18:1 DAP
Linear Formula: C41H77NO4
CAS Number: 127512-29-2
Formula Weight: 648.1
Formulation: Oil
Purity: ≥98%
Solubility in Different Solvents: Soluble in ethanol, DMSO, and Chloroform:Methanol:Water (65:25:4) at 5mg/mL
Shipping: Room Temperature in North America; may vary elsewhere.
Storage: -20°C
Key Features/Applications:
  • High transfection efficiency and low cytotoxicity
  • Efficient delivery of plasmid DNA, siRNA/miRNA, and CRISPR/Cas9 components
  • Widely used in nanomedicine
  • Used as a component of lipid bilayers
  • Used in the formulation of stable nucleic acid-lipid vesicles
  • in the preparation of targeted or non-targeted liposomes

Additional information

Price in Canadian Dollar

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